Interactomics of oral fluids

口腔液相互作用组学

• 批准号: 371813-2009
• 负责人: Siqueira, Walter
• 金额: $ 2.11万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528381
• 关键词: Interactomics; oral; fluids

We hypothesize that the interactions among salivary proteins protect complex partners from proteolysis, modulate the biological activity of complexed proteins or serve as a delivery system for the distribution of secretory salivary proteins throughout the oral cavity. Since no detailed analyses of the salivary protein complexes present in whole saliva and salivary gland secretions have been carried out yet, these roles will be investigated in detail in the current proposal. State-of-the-art proteomics will be used, in combination with classical protein-protein interaction methods, to provide a greater understanding of the biological function of salivary protein complexes.

我们假设，唾液蛋白之间的相互作用保护复杂的伴侣免受蛋白质分解的影响，调节复杂蛋白的生物活性，或者作为分泌唾液蛋白在口腔中分布的输送系统。由于尚未对整个唾液和唾液腺分泌物中存在的唾液蛋白复合体进行详细分析，因此将在当前的提案中详细研究这些作用。最先进的蛋白质组学将与经典的蛋白质相互作用方法相结合，以更好地了解唾液蛋白质复合体的生物学功能。