Interactomics of oral fluids

我们假设唾液蛋白之间的相互作用可以保护复杂的伴侣免受蛋白质水解，调节复杂蛋白的生物活性，或者作为唾液分泌蛋白在口腔内分布的传递系统。由于目前还没有对整个唾液和唾液腺分泌物中存在的唾液蛋白复合物进行详细分析，因此本文将对这些作用进行详细的研究。最先进的蛋白质组学将与经典的蛋白质-蛋白质相互作用方法相结合，以更好地了解唾液蛋白复合物的生物学功能。

We hypothesize that the interactions among salivary proteins protect complex partners from proteolysis, modulate the biological activity of complexed proteins or serve as a delivery system for the distribution of secretory salivary proteins throughout the oral cavity. Since no detailed analyses of the salivary protein complexes present in whole saliva and salivary gland secretions have been carried out yet, these roles will be investigated in detail in the current proposal. State-of-the-art proteomics will be used, in combination with classical protein-protein interaction methods, to provide a greater understanding of the biological function of salivary protein complexes.