Understanding age-related protein aggregation. The mechanism of cataract and its prevention

了解与年龄相关的蛋白质聚集。

• 批准号: nhmrc : GNT1068087
• 负责人: Prof Andrew Abell
• 金额: $ 45.81万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-age-related-cataract-prevention/1344946
• 关键词: Understanding; age; related; protein; aggregation.

Cataract arises from clouding of the eye lens due to the aggregation of crystallin proteins whose high concentration and close packing facilitate lens transparency. This proposal will investigate crystallin structure and interactions to understand the reasons for cataract formation and its prevention via the design of aggregation inhibitors. The results will facilitate the development of drugs to prevent cataract and other related protein aggregation diseases, e.g. Alzheimer’s and Parkinson’s.

白内障是由于晶状体蛋白的聚集而使眼透镜混浊而引起的，晶状体蛋白的高浓度和紧密堆积促进了透镜的透明度。本研究将探讨晶体蛋白的结构和相互作用，以了解白内障形成的原因，并通过设计聚集抑制剂来预防白内障。研究结果将有助于开发预防白内障和其他相关蛋白质聚集疾病（如阿尔茨海默氏症和帕金森氏症）的药物。