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Understanding age-related protein aggregation. The mechanism of cataract and its prevention

Understanding age-related protein aggregation. The mechanism of cataract and its prevention
了解与年龄相关的蛋白质聚集。
批准号:
nhmrc : 1068087
负责人:
Prof Andrew Abell
金额:
$47.3万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

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中文摘要
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英文摘要
Cataract arises from clouding of the eye lens due to the aggregation of crystallin proteins whose high concentration and close packing facilitate lens transparency. This proposal will investigate crystallin structure and interactions to understand the reasons for cataract formation and its prevention via the design of aggregation inhibitors. The results will facilitate the development of drugs to prevent cataract and other related protein aggregation diseases, e.g. Alzheimer’s and Parkinson’s.
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Understanding age-related protein aggregation. The mechanism of cataract and its prevention
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    Project Grants
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    $45.81万
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    Prof Andrew Abell
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