Understanding cortical circuitry underlying sensory integration and the consequence of its developmental disruption

了解感觉统合背后的皮层电路及其发育障碍的后果

• 批准号: nhmrc : 1124411
• 负责人: A/Pr Ehsan Arabzadeh
• 金额: $ 36.03万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-cortical-circuitry-developmental-disruption/947341
• 关键词: Understanding; cortical; circuitry; underlying; sensory

The mammalian neocortex is organised into six layers with a systematic pattern of wiring that relies on normal development and balanced activity of neurons. This project combines developmental, electrophysiological, optogenetic behavioural, and computational methods to establish how the properties of the precise structure of cortical circuits impact their function and how disruptions in the balanced activity during development affect circuit formation and function in the mature brain.

哺乳动物的新皮层被组织成六层，其系统的布线模式依赖于正常的发育和神经元的平衡活动。该项目结合了发育、电生理学、光遗传行为学和计算方法，以确定皮层回路精确结构的特性如何影响其功能，以及发育过程中平衡活动的中断如何影响成熟大脑中的回路形成和功能。