Understanding epigenetic modification during oogenesis for novel treatments of female infertility

了解卵子发生过程中的表观遗传修饰以用于女性不孕症的新疗法

• 批准号: nhmrc : GNT1112766
• 负责人: Dr Deepak Adhikari
• 金额: $ 31.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-epigenetic-modification-female-infertility/1346821
• 关键词: Understanding; epigenetic; modification; during; oogenesis

Infertility affects about 10% of Australian women and the success rates of current infertility treatments are low due to our poor knowledge of eggs development. The numbers of obese and older women trying to conceive are increasing; fertility treatments are even less effective for them. I have generated mouse models to elucidate the pathways regulating egg development. I will study for alterations in these pathways in the mouse models which perfectly mimic the obesity and aging in women.

不孕症影响约10%的澳大利亚妇女，目前不孕症治疗的成功率很低，因为我们对卵子发育的知识不足。试图怀孕的肥胖和老年妇女的数量正在增加;生育治疗对她们的效果更差。我已经建立了小鼠模型来阐明调节卵子发育的途径。我将在小鼠模型中研究这些通路的改变，这些小鼠模型完美地模拟了女性的肥胖和衰老。