The UNC Chapel Hill Superfund Research Program (UNC-SRP)

北卡罗来纳大学教堂山超级基金研究计划 (UNC-SRP)

• 批准号: 10797455
• 负责人: Rebecca Fry
• 金额: $ 1.26万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-02 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10797455
• 关键词: Address; Amendment; Arsenic; Authorization documentation; Biological; Businesses; Chemical Exposure; Chemistry; Collaborations; Communication; Communities; Complex Mixtures; Data Analyses; Development; Diabetes Mellitus; Disease; Ensure; Environmental Science; Excision; Exposure to; Foundations; Future; Genotype; Gestational Age; Human; In Vitro; Individual; Industrialization; Industry; Institution; Intervention; Knowledge; Lead; Life; Link; Mediating; Metabolic Diseases; Metabolic dysfunction; Metal exposure; Metals; Methods; Methyltransferase; MicroRNAs; Mission; Molecular; North Carolina; Placenta; Pollution; Population; Predisposition; Prevalence; Prevention; Privatization; Proteins; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Research Technics; Rivers; Sampling; Science; Scientist; Signal Recognition Particle; Soil; Source; Southeastern United States; Superfund; Technology; Training; Translating; Translational Research; United States; Universities; Vision; Water; Wood material; Work; authority; biomarker identification; coal ash; community engagement; data integration; data management; diabetes risk; disorder prevention; disorder risk; drinking; environmental chemical; environmental justice; epidemiology study; experience; exposed human population; gut microbiome; in vivo Model; innovation; interdisciplinary approach; next generation; novel; novel strategies; prenatal exposure; prevent; programs; rural area; superfund site; transcription factor; vulnerable community

PROJECT DESCRIPTION Summary: While prenatal exposure to environmental metals, such as inorganic arsenic, is associated with decreased gestational age, there is a fundamental knowledge gap regarding the placental molecular drivers of this association. Numerous epidemiological studies have associated exposure to individual environmental metals, such as inorganic arsenic and lead, with decreased gestational age. Often such studies analyze chemical exposures individually instead of in mixtures. This analytical approach does not reflect the fact that humans are exposed to complex mixtures of environmental chemicals that may have interactive or synergistic effects. Ignoring the possibility of these combined effects may obscure the full extent of the association between exposure to environmental metals and gestational age. This project will examine the association between exposure to environmental metals early in life and gestational age. The metals will be analyzed individually as well as a mixture. Subsequently, to identify biological mechanisms underlying this association, we will identify specific miRNAs and proteins within the placenta that may mediate the association between metal exposure and gestational age.

项目描述

项目成果

Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics.

• DOI: 10.1038/s41370-022-00451-8
• 发表时间: 2022-11
• 期刊: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
• 影响因子: 4.5
• 作者: Koval, Lauren E.;Dionisio, Kathie L.;Friedman, Katie Paul;Isaacs, Kristin K.;Rager, Julia E.
• 通讯作者: Rager, Julia E.

A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm.

• DOI: 10.1093/toxsci/kfac097
• 发表时间: 2022-11-23
• 期刊: Toxicological sciences : an official journal of the Society of Toxicology

Analysis of the novel NCWELL database highlights two decades of co-occurrence of toxic metals in North Carolina private well water: Public health and environmental justice implications.

• DOI: 10.1016/j.scitotenv.2021.151479
• 发表时间: 2022-03-15
• 期刊: SCIENCE OF THE TOTAL ENVIRONMENT
• 影响因子: 9.8
• 作者: Eaves, Lauren A.;Keil, Alexander P.;Rager, Julia E.;George, Andrew;Fry, Rebecca C.
• 通讯作者: Fry, Rebecca C.

Hydrolytically Stable Ionic Fluorogels for High-Performance Remediation of Per- and Polyfluoroalkyl Substances (PFAS) from Natural Water.

• DOI: 10.1002/anie.202208150
• 发表时间: 2022-10-10
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Manning, Irene M.;Chew, Nick Guan Pin;Macdonald, Haley P.;Miller, Kelsey E.;Strynar, Mark J.;Coronell, Orlando;Leibfarth, Frank A.
• 通讯作者: Leibfarth, Frank A.

Correlating the Role of Nanofillers with Active Layer Properties and Performance of Thin-Film Nanocomposite Membranes.

• DOI: 10.1016/j.desal.2023.116370
• 发表时间: 2023-03
• 期刊: Desalination
• 影响因子: 9.9
• 作者: L. Perry;N. Chew;Kasia Grzebyk;Pinar Cay-Durgun;M. Lind;Paban Sitaula;M. Soukri;O. Coronell