Ventricular remodelling in cardiomyopathy _ impact on ventricular physiology and cardiovascular outcome.

心肌病的心室重塑_对心室生理和心血管结局的影响。

• 批准号: nhmrc : 1017819
• 负责人: Dr Andris Ellims
• 金额: $ 8.22万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ventricular-remodelling-cardiomyopathy-cardiovascular-outcome/109917
• 关键词: Ventricular; remodelling; cardiomyopathy; impact; ventricular

Diffuse myocardial fibrosis is the widespread deposition of scar tissue in heart muscle and is a common final pathway of cardiac disease. A new technique (contrast-enhanced T1 mapping) using cardiac magnetic resonance imaging can non-invasively detect this scarring. The proposed research intends to further determine the significance of diffuse myocardial fibrosis in cardiac disease, evaluate its link with diastolic heart failure and examine the potential therapeutic role of anti-fibrotic agents.

弥漫性心肌纤维化是心肌中广泛存在的瘢痕组织沉积，是心脏疾病常见的最终途径。一种使用心脏磁共振成像的新技术(对比度增强T1映射)可以非侵入性地检测到这种疤痕。这项拟议的研究旨在进一步确定弥漫性心肌纤维化在心脏病中的意义，评估其与舒张性心力衰竭的联系，并检查抗纤维化药物的潜在治疗作用。