Influence of sex and 17-B-estradiol on metabolism and inflammation in skeletal muscle
Influence of sex and 17-B-estradiol on metabolism and inflammation in skeletal muscle
批准号:
183817-2007
负责人:
Tarnopolsky, Mark
金额:
$2.29万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2010
资助国家:
加拿大
项目状态:
已结题
起止时间:
2010-01-01 至 2011-12-31
中文摘要
1. 男性和女性在耐力运动中使用不同的燃料,与男性相比,女性燃烧的脂肪更多,碳水化合物和蛋白质更少。通过给男性补充雌激素(女性性激素),我们发现他们在运动时的代谢谱与女性相似。我们已经开始使用生化和分子分析在肌肉细胞水平上表征这些雌激素的作用,并希望使用全基因组分析(基因芯片)的强大方法进一步表征这些作用。我们还将使用缺乏雌激素受体的转基因动物来确定细胞受体在介导代谢作用中的作用。
英文摘要
1. Men and women use different fuels during endurance exercise with women burning more fat and less carbohydrate and protein as compared with men. By giving estrogen (the female sex hormone) supplements to men, we found that they had a similar metabolic profile to that seen in women during exercise. We have started to characterize these estrogen effects at the level of the muscle cell using biochemical and molecular analyses and would like to further characterize these effects using powerful methods of entire genome profiling (gene chips). We will also use trangenic animals lacking the estrogen receptor to determine what role the cell receptor has in mediating the metabolic effects.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
"Exercise Mediated Systemic Cellular Protection - ""Exerkines"""
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批准号:183817-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2016
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负责人:Tarnopolsky, Mark
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依托单位:
"Exercise Mediated Systemic Cellular Protection - ""Exerkines"""
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批准号:183817-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2015
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负责人:Tarnopolsky, Mark
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依托单位:
"Exercise Mediated Systemic Cellular Protection - ""Exerkines"""
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批准号:183817-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2014
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负责人:Tarnopolsky, Mark
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依托单位:
"Exercise Mediated Systemic Cellular Protection - ""Exerkines"""
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批准号:183817-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2013
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负责人:Tarnopolsky, Mark
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依托单位:
"Exercise Mediated Systemic Cellular Protection - ""Exerkines"""
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批准号:183817-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2012
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负责人:Tarnopolsky, Mark
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依托单位:
Optimization of exercise training programs based on in vivo molecular outcomes
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批准号:365655-2009
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项目类别:Collaborative Health Research Projects
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资助金额:$5.42万
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财政年份:2011
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负责人:Tarnopolsky, Mark
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依托单位:
Influence of sex and 17-B-estradiol on metabolism and inflammation in skeletal muscle
-
批准号:183817-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.29万
-
财政年份:2011
-
负责人:Tarnopolsky, Mark
-
依托单位:
Optimization of exercise training programs based on in vivo molecular outcomes
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批准号:365655-2009
-
项目类别:Collaborative Health Research Projects
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资助金额:$6.27万
-
财政年份:2010
-
负责人:Tarnopolsky, Mark
-
依托单位:
Optimization of exercise training programs based on in vivo molecular outcomes
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批准号:365655-2009
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项目类别:Collaborative Health Research Projects
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资助金额:$6.02万
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财政年份:2009
-
负责人:Tarnopolsky, Mark
-
依托单位:
Influence of sex and 17-B-estradiol on metabolism and inflammation in skeletal muscle
-
批准号:183817-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.29万
-
财政年份:2009
-
负责人:Tarnopolsky, Mark
-
依托单位:
Influence of sex and 17-B-estradiol on metabolism and inflammation in skeletal muscle
-
批准号:183817-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.29万
-
财政年份:2008
-
负责人:Tarnopolsky, Mark
-
依托单位:
Influence of sex and 17-B-estradiol on metabolism and inflammation in skeletal muscle
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批准号:183817-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.29万
-
财政年份:2007
-
负责人:Tarnopolsky, Mark
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依托单位:
Gender differences in protein metabolism and oxidative stress/apoptosis
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批准号:183817-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2006
-
负责人:Tarnopolsky, Mark
-
依托单位:
Gender differences in protein metabolism and oxidative stress/apoptosis
-
批准号:183817-2001
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.19万
-
财政年份:2005
-
负责人:Tarnopolsky, Mark
-
依托单位:
Gender differences in protein metabolism and oxidative stress/apoptosis
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批准号:183817-2001
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项目类别:Discovery Grants Program - Individual
-
资助金额:$2.19万
-
财政年份:2003
-
负责人:Tarnopolsky, Mark
-
依托单位:
Gender differences in protein metabolism and oxidative stress/apoptosis
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批准号:183817-2001
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项目类别:Discovery Grants Program - Individual
-
资助金额:$2.19万
-
财政年份:2002
-
负责人:Tarnopolsky, Mark
-
依托单位:
Gender differences in protein metabolism and oxidative stress/apoptosis
-
批准号:183817-2001
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.19万
-
财政年份:2001
-
负责人:Tarnopolsky, Mark
-
依托单位:
Gender differences in protein metabolism and oxidative stress/apoptosis
-
批准号:183817-2001
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.19万
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财政年份:2000
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负责人:Tarnopolsky, Mark
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依托单位:
An HPLC upgrade for the determination of oxidative stress markers in muscle and plasma
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批准号:240736-2001
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$1.47万
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财政年份:2000
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负责人:Tarnopolsky, Mark
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依托单位:
Gender differences in metabolism: nutritional implications
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批准号:183817-1996
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.1万
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财政年份:1999
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负责人:Tarnopolsky, Mark
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依托单位:
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