A new reference atlas of brain networks to investigate neuropsychiatric traits in adolescents

用于研究青少年神经精神特征的新大脑网络参考图集

基本信息

  • 批准号:
    10585096
  • 负责人:
  • 金额:
    $ 8.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-26 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Adolescence is typically defined as the transition period between childhood and adulthood. It is a critical period for neural changes, including maturation of the brain’s cognitive networks, but also a period of increased vulnerability to psychopathology. It is well accepted that the brain is functionally organized into multiple interacting networks and extensive literature has demonstrated that the spatial and functional organization of these networks shows major age-related changes across the lifespan, but particularly during adolescence. Yet, there is currently no reference functional brain atlas derived from typically-developing adolescents, which is especially problematic as the reliable and reproducible identification of functional brain networks crucially depends on the use of such reference functional atlases. Furthermore, the use of atlases derived from adults may undermine the validity and reliability of developmental neuroimaging research. Using preliminary data for this application and previous works, we show that an age-appropriate functional brain atlas will improve the characterization of the brain functional connectome and its links to neuropsychiatric traits in youth. In this context, the aim of this application is to construct and validate the first reference functional brain atlas in typically-developing youth between the age of 8 and 17 years. To achieve this, we will use resting-state functional MRI (rs-fMRI) from the three largest developmental neuroimaging datasets. Our first aim (Aim 1) is to generate a reference atlas, called “Dev-Atlas”, using the rs-fMRI datasets from approximately 2,000 youths. We will then (Aim 2) demonstrate the replicability of Dev-Atlas in two independent large samples of typically- developing youth (Dev-Cog: n=230; Dev-MIND: n=310), collected at Boys Town National Research Hospital and the Mind Research Network. Because girls, on average, enter puberty one to two years earlier than boys, we will test (Aim 3) whether girls show brain network differences compared to boys. In the event of significant sex differences, we will create the first sex-specific functional brain atlases for youth. Finally, we will demonstrate the superiority of network connectivity features derived from Dev-Atlas compared to atlases based on data from adults in predicting a greater amount of the variance in psychiatric traits (Aim 4). The successful completion of this project will provide the first reliable functional brain atlas for youth aged 8-17 years old, which will be made freely available to the research community. By mapping the brain functional connectome underlying childhood and adolescence, this work has the potential to elucidate how brain network dysfunction contributes to psychiatric traits and the risk for mental health disorders in adolescence.
PROJECT SUMMARY Adolescence is typically defined as the transition period between childhood and adulthood. It is a critical period for neural changes, including maturation of the brain’s cognitive networks, but also a period of increased vulnerability to psychopathology. It is well accepted that the brain is functionally organized into multiple interacting networks and extensive literature has demonstrated that the spatial and functional organization of these networks shows major age-related changes across the lifespan, but particularly during adolescence. Yet, there is currently no reference functional brain atlas derived from typically-developing adolescents, which is especially problematic as the reliable and reproducible identification of functional brain networks crucially depends on the use of such reference functional atlases. Furthermore, the use of atlases derived from adults may undermine the validity and reliability of developmental neuroimaging research. Using preliminary data for this application and previous works, we show that an age-appropriate functional brain atlas will improve the characterization of the brain functional connectome and its links to neuropsychiatric traits in youth. In this context, the aim of this application is to construct and validate the first reference functional brain atlas in typically-developing youth between the age of 8 and 17 years. To achieve this, we will use resting-state functional MRI (rs-fMRI) from the three largest developmental neuroimaging datasets. Our first aim (Aim 1) is to generate a reference atlas, called “Dev-Atlas”, using the rs-fMRI datasets from approximately 2,000 youths. We will then (Aim 2) demonstrate the replicability of Dev-Atlas in two independent large samples of typically- developing youth (Dev-Cog: n=230; Dev-MIND: n=310), collected at Boys Town National Research Hospital and the Mind Research Network. Because girls, on average, enter puberty one to two years earlier than boys, we will test (Aim 3) whether girls show brain network differences compared to boys. In the event of significant sex differences, we will create the first sex-specific functional brain atlases for youth. Finally, we will demonstrate the superiority of network connectivity features derived from Dev-Atlas compared to atlases based on data from adults in predicting a greater amount of the variance in psychiatric traits (Aim 4). The successful completion of this project will provide the first reliable functional brain atlas for youth aged 8-17 years old, which will be made freely available to the research community. By mapping the brain functional connectome underlying childhood and adolescence, this work has the potential to elucidate how brain network dysfunction contributes to psychiatric traits and the risk for mental health disorders in adolescence.

项目成果

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专利数量(0)

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Gaelle Eve Doucet其他文献

Gaelle Eve Doucet的其他文献

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{{ truncateString('Gaelle Eve Doucet', 18)}}的其他基金

Developmental changes in the reconfiguration of brain networks and their association with psychiatric traits during adolescence
青春期大脑网络重构的发育变化及其与精神特征的关联
  • 批准号:
    10346727
  • 财政年份:
    2022
  • 资助金额:
    $ 8.1万
  • 项目类别:
Developmental changes in the reconfiguration of brain networks and their association with psychiatric traits during adolescence
青春期大脑网络重构的发育变化及其与精神特征的关联
  • 批准号:
    10580786
  • 财政年份:
    2022
  • 资助金额:
    $ 8.1万
  • 项目类别:
Atlas55+: Creation and Validation of a Reference Brain Functional Atlas for Late Adulthood
Atlas55:成年晚期参考脑功能图谱的创建和验证
  • 批准号:
    9803960
  • 财政年份:
    2019
  • 资助金额:
    $ 8.1万
  • 项目类别:
Reconfiguration of brain networks and its association with cognition across the lifespan
大脑网络的重构及其与整个生命周期认知的关联
  • 批准号:
    10161648
  • 财政年份:
  • 资助金额:
    $ 8.1万
  • 项目类别:

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