A global approach to structure, assembly and function of yeast mitochondrial ATP synthase

酵母线粒体ATP合酶的结构、组装和功能的整体方法。ATP合成酶负责合成活细胞中普遍存在的能量物质ATP。这种多亚基酶复合物是分子旋转马达，其机制依赖于复合物的组分蛋白质亚基的功能动态相互作用。使用强大的和复杂的分子生物学技术的组合的功能和动态的接触，由复合物内的亚基，或ATP合酶和其他酶复合物参与能源生产（包括其他ATP合酶复合物）之间进行调查。将获得对生命中最基本和最具挑战性的酶之一的新的和重要的见解。

A global approach to structure, assembly and function of yeast mitochondrial ATP synthase. ATP synthase is responsible for the synthesis of the ubiquitous energy substance ATP in living cells. This multisubunit enzyme complex is a molecular rotatory motor whose mechanism relies on functional dynamic interactions of the component protein subunits of the complex. Using a combination of powerful and sophisticated molecular biology techniques the functional and dynamic contacts made by subunits within the complex, or between ATP synthase and other enzyme complex involved in energy production (including other ATP synthase complexes) will be investigated. New and significant insights into one of the most fundamental and challenging enzymes of life will be obtained.