Design, modeling, fabrication and testing of integrated optical and bio microsystems

用于健康监测和诊断的生物安全和即时检测（POCT）是快速检测生物和化学物种的时代需求，对于各种医疗应用至关重要。这就要求有必要开发一种具有成本效益的能够快速原位检测生物元素的微系统。集成微系统通过将光学与生物学相结合，解决了快速病原检测的问题。然而，生物光子学存在一些关键问题，如微型化、便携性等。现场医学检测需要设备的便携性，而生物传感器的小型化对于处理更小的样本量至关重要，以实现高通量。除非开发一种集成微系统的技术，否则这两个条件都无法满足。因此，集成光学和生物微系统领域在药物输送、医疗诊断、芯片实验室、生物防御、生物传感器、护理点诊断应用、治疗微/纳米技术、微阵列和生物芯片、蛋白质阵列、生物测定等方面具有巨大的潜力，将极大地造福社会。

Bio-security and Point-of-Care Testing (POCT) for health monitoring and diagnosis are the needs of the hour for rapid detection of biological and chemical species, and essential for various medical applications. This calls for a necessity to develop a cost effective Microsystems capable of rapid in-situ detection of biological elements. Integrated microsystems provide an answer to the problems of rapid pathogenic detections by integrating optics with biology. However, there are some critical issues which are associated with biophotonics such as miniaturization, portability etc. The portability of the device is required for in-situ medical detections while miniaturization of the biosensor is essential for handling smaller sample volumes in order to achieve high throughput. Both these conditions cannot be satisfied unless a technology to integrate microsystems is developed. Hence, the field of integrated Optical and Bio Mircrosystems has vast potential for drug delivery, medical diagnosis, lab-on-a-chip, biodefense, biosensors, point-of-care diagnostic applications, therapeutic micro/nano technologies, microarrays and biochips, protein arrays, bioassays, etc. that would benefit the society enormously.