Fluorimetric analysis of voltage-gated ion channel gating

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Ion channels are proteins that form ion-selective pores within cell membranes. They control membrane excitability and are therefore critical determinants of cellular function. Voltage-gated potassium (Kv) channels, which are a very diverse family of ion channel, are highly selective for potassium ions (K+) and open (gates) in response to changes in the voltage across the cell membrane. Despite their critical role in regulating excitability in cardiac, nerve, and endocrine cells, dynamic structural information regarding key Kv channel gating mechanisms is lacking.