Bayesian models for long-range population genetics
远程群体遗传学的贝叶斯模型
基本信息
- 批准号:371895-2009
- 负责人:
- 金额:$ 1.89万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2010
- 资助国家:加拿大
- 起止时间:2010-01-01 至 2011-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Two quite different perspectives can be taken on the problem of species evolution. The historical perspective consists in reconstructing the evolutionary history of all living species (the tree of life), based on fossil evidence and molecular sequence comparisons. This is the task of phylogenetics. Recently, it has motivated important statistical efforts so as to provide reliable tree reconstructions. The demographic and mechanistic perspective, on the other hand, is more concerned with understanding how the intricate interplay between mutation, selection and random drift determines the mode of evolution of extant species, down to the molecular level. It also tries to understand how the ecological factors experienced by a species (such as its population size) influence this interplay. Population genetics provides the theoretical framework for such an understanding. Classical population genetics achieves its aims mainly by observing the distribution of intra-specific genetic diversity (polymorphisms). However, it is progressively understood that very valuable information can also be derived from the large-scale comparative analyses performed by phylogeneticists. This information is less detailed than that derived from polymorphisms. However, it reaches much further back in time, raising the exciting possibility that by reading it out, one could reconstruct the evolution of essential ecological factors experienced by species along the tree of life.
在物种进化问题上可以采取两种截然不同的观点。历史观点在于根据化石证据和分子序列比较重建所有活着的物种(生命之树)的进化史。这就是系统发育学的任务。最近,它推动了重要的统计努力,以便提供可靠的树重建。另一方面,人口统计学和机械论的观点更关心的是理解突变、选择和随机漂移之间的复杂相互作用如何决定现有物种的进化模式,一直到分子水平。它还试图理解一个物种所经历的生态因素(如其种群规模)如何影响这种相互作用。种群遗传学为这种理解提供了理论框架。经典的群体遗传学主要通过观察种内遗传多样性(多态)的分布来实现其目的。然而,人们逐渐认识到,也可以从系统发育学家进行的大规模比较分析中获得非常有价值的信息。这些信息没有从多态中获得的信息那么详细。然而,它可以追溯到更早的时间,增加了一种令人兴奋的可能性,即通过朗读它,人们可以重建生命之树上物种经历的基本生态因素的进化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lartillot, Nicolas其他文献
History Can Matter: Non-Markovian Behavior of Ancestral Lineages
- DOI:
10.1093/sysbio/syr012 - 发表时间:
2011-05-01 - 期刊:
- 影响因子:6.5
- 作者:
Cartwright, Reed A.;Lartillot, Nicolas;Thorne, Jeffrey L. - 通讯作者:
Thorne, Jeffrey L.
Empirical profile mixture models for phylogenetic reconstruction
- DOI:
10.1093/bioinformatics/btn445 - 发表时间:
2008-10-15 - 期刊:
- 影响因子:5.8
- 作者:
Quang, Le Si;Gascuel, Olivier;Lartillot, Nicolas - 通讯作者:
Lartillot, Nicolas
Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles
- DOI:
10.1073/pnas.0910915107 - 发表时间:
2010-03-09 - 期刊:
- 影响因子:11.1
- 作者:
Rodrigue, Nicolas;Philippe, Herve;Lartillot, Nicolas - 通讯作者:
Lartillot, Nicolas
Improvement of molecular phylogenetic inference and the phylogeny of Bilateria
- DOI:
10.1098/rstb.2007.2236 - 发表时间:
2008-04-27 - 期刊:
- 影响因子:6.3
- 作者:
Lartillot, Nicolas;Philippe, Herve - 通讯作者:
Philippe, Herve
Probabilistic models of eukaryotic evolution: time for integration
- DOI:
10.1098/rstb.2014.0338 - 发表时间:
2015-09-26 - 期刊:
- 影响因子:6.3
- 作者:
Lartillot, Nicolas - 通讯作者:
Lartillot, Nicolas
Lartillot, Nicolas的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lartillot, Nicolas', 18)}}的其他基金
Bayesian models for long-range population genetics
远程群体遗传学的贝叶斯模型
- 批准号:
371895-2009 - 财政年份:2013
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Bayesian models for long-range population genetics
远程群体遗传学的贝叶斯模型
- 批准号:
371895-2009 - 财政年份:2012
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Bayesian models for long-range population genetics
远程群体遗传学的贝叶斯模型
- 批准号:
371895-2009 - 财政年份:2011
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Bayesian models for long-range population genetics
远程群体遗传学的贝叶斯模型
- 批准号:
371895-2009 - 财政年份:2009
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
Scalable Learning and Optimization: High-dimensional Models and Online Decision-Making Strategies for Big Data Analysis
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:合作创新研究团队
河北南部地区灰霾的来源和形成机制研究
- 批准号:41105105
- 批准年份:2011
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
保险风险模型、投资组合及相关课题研究
- 批准号:10971157
- 批准年份:2009
- 资助金额:24.0 万元
- 项目类别:面上项目
RKTG对ERK信号通路的调控和肿瘤生成的影响
- 批准号:30830037
- 批准年份:2008
- 资助金额:190.0 万元
- 项目类别:重点项目
新型手性NAD(P)H Models合成及生化模拟
- 批准号:20472090
- 批准年份:2004
- 资助金额:23.0 万元
- 项目类别:面上项目
相似海外基金
Integrating Large Language Models for Long Horizon Task Planning in Multi-robot Scenarios
集成大型语言模型以实现多机器人场景中的长期任务规划
- 批准号:
24K07399 - 财政年份:2024
- 资助金额:
$ 1.89万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering How Stress Induced Histomorphogenesis Effects the Long-term Leaching from an Implanted Medical Device using Phase Field Models
使用相场模型发现应力诱导的组织形态发生如何影响植入医疗器械的长期浸出
- 批准号:
2309538 - 财政年份:2024
- 资助金额:
$ 1.89万 - 项目类别:
Standard Grant
Simulating the Spread and Control of Multiple MDROs Across a Network of Different Nursing Homes
模拟多个 MDRO 在不同疗养院网络中的传播和控制
- 批准号:
10549492 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
CAREER: Analysis of uncertainty, long-time statistics and singularity formation in fluid flow models
职业:流体流动模型中的不确定性、长期统计数据和奇点形成分析
- 批准号:
2239325 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Continuing Grant
A Refined Murine Model of Post-sepsis Cognitive Impairment for Investigating Mitochondrial Abnormalities and Human ApoE4 Gene Polymorphisms
用于研究线粒体异常和人类 ApoE4 基因多态性的精制脓毒症后认知障碍小鼠模型
- 批准号:
10646579 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Trial of a harm reduction strategy for people with HIV who smoke cigarettes
针对吸烟的艾滋病毒感染者的减害策略试验
- 批准号:
10696463 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Epitope-Based CSP Vaccines Optimized to Achieve Long-Term Sterile Immunity
经过优化的基于表位的 CSP 疫苗可实现长期无菌免疫
- 批准号:
10637778 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Mentoring Emerging Researchers at CHLA (MERCH-LA)
指导 CHLA (MERCH-LA) 的新兴研究人员
- 批准号:
10797938 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Supplement for Cloud Computing: Alcohol Use Disorder Treatment Simulation
云计算补充:酒精使用障碍治疗模拟
- 批准号:
10827563 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Comprehensive Long COVID Care for Underserved Communities: Innovative Delivery and Dissemination Models (Comunidad)
为服务不足的社区提供全面的长期新冠护理:创新的交付和传播模式 (Comunidad)
- 批准号:
10866175 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别: