A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules

维生素 D 非基因组作用的研究：核 VDR 和下游信号分子的拟议作用

• 批准号: ARC : DP0210630
• 负责人: A/Prof Brian May
• 金额: $ 18万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/a-study-nongenomic-signalling-molecules/72745
• 关键词: study; nongenomic; action; Vitamin; proposed

A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.

维生素D的非基因组作用的研究：核VDR及其下游信号分子的作用建议。维生素D(1，25D)通过维生素D受体(VDR)激活细胞核中的基因。1，25D也能在质膜上引起快速反应。这一作用对核基因的激活至关重要。我们假设，核VDR的一部分位于质膜上，在那里它刺激下游的信号分子，如RAS、ERK1/2和ERK5。我们计划探索这一假说，并确定信号分子。我们还将研究我们的新发现，即特定的RAS亚型参与ERK5的激活。这项工作将提供有关信号通路的新信息。