Natural polymer scaffolds and gene-loaded nanoparticles for tissue engineering

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The long-term objective of the proposed research program is to develop gene-loaded nanoparticles and bioactive scaffolds for tissue repair and reconstitution using biocompatible and biodegradable natural polymers. The short-term objectives are 1) to design and characterize nanoparticles for gene delivery, created from natural polymers; 2) to fabricate and characterize collagen-based composite scaffolds that mimic cell living environment; 3) to evaluate transfection efficiency and safety of gene-loaded nanoparticles in mesenchymal stem cells(MSCs)-seeded scaffolds.