Natural polymer scaffolds and gene-loaded nanoparticles for tissue engineering

用于组织工程的天然聚合物支架和基因负载纳米粒子

• 批准号: 386361-2010
• 负责人: Xing, Malcolm(Mengqiu)
• 金额: $ 1.31万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=463758
• 关键词: Natural; polymer; scaffolds; gene; loaded

The long-term objective of the proposed research program is to develop gene-loaded nanoparticles and bioactive scaffolds for tissue repair and reconstitution using biocompatible and biodegradable natural polymers. The short-term objectives are 1) to design and characterize nanoparticles for gene delivery, created from natural polymers; 2) to fabricate and characterize collagen-based composite scaffolds that mimic cell living environment; 3) to evaluate transfection efficiency and safety of gene-loaded nanoparticles in mesenchymal stem cells(MSCs)-seeded scaffolds.

拟议研究计划的长期目标是开发基因加载纳米粒子和生物活性支架，用于使用生物相容性和可生物降解的天然聚合物进行组织修复和重建。短期目标是：1）设计和表征用于基因递送的纳米颗粒，由天然聚合物制成; 2）制造和表征模拟细胞生活环境的基于胶原蛋白的复合支架; 3）评估载基因纳米颗粒在间充质干细胞（MSC）接种支架中的转染效率和安全性。