High-throughput sequencer for life science research

下一代DNA测序（也称为高通量测序）技术正在彻底改变科学家进行研究的方式。这些技术可以一次对数百万个DNA碱基对进行测序，并为研究人员提供分析个体基因组序列、复杂微生物群落或一种组织或细胞类型中所有基因表达水平的能力。下一代测序是分子生物学研究的未来，纽芬兰纪念大学高通量测序仪的可用性对于保持高水平的卓越研究至关重要。此外，可靠、负担得起和有保证地获得这项技术对于研究人员保持与世界各地的研究人员的竞争力至关重要。该仪器将支持纪念大学3个不同单位的11个nserc资助的研究实验室的研究项目，涵盖广泛的生命科学研究。这些研究包括微生物学、海洋生物学、动物生理学、植物病害、群体遗传学、发育生物学和免疫学。同时分析数千种不同基因的DNA序列将使申请人能够确定有助于鱼类、植物和其他模式生物和非模式生物的健康、生长、发育和免疫功能的序列变化。此外，病毒介导的遗传交换、野生病毒运动和新的抗微生物分子的鉴定等研究也依赖于该技术来推进这些研究领域的知识。

Next-generation DNA sequencing (also called high-throughput sequencing) technologies are revolutionizing the way that scientists do research. These technologies allow the sequencing of millions of base pairs of DNA at one time and provide researchers with the ability to analyze individual genome sequences, complex microbial communities or the expression levels of all genes in one tissue or cell type. Next-generation sequencing is the future of molecular biology research and the availability of a high-throughput sequencer at Memorial University of Newfoundland is essential to maintain a high level of research excellence. In addition, reliable, affordable and guaranteed access to this technology is crucial for researchers to remain competitive with researchers from around the world. The instrument requested will support the research programs of 11 NSERC-funded research labs from 3 different units at Memorial University, spanning a wide spectrum of life science research. These include research in microbiology, marine biology, animal physiology, plant diseases, population genetics, developmental biology and immunology. Analysis of DNA sequences of thousands of different genes simultaneously will allow the applicants to identify sequence changes that contribute to the health, growth, development and immune function of fish, plants and other model and non-model organisms. In addition, research on virus-mediated genetic exchange, wild virus movement and identification of new anti-microbial molecules is also dependent on this technology to advance the knowledge in these research areas.