Neural development

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I propose continuation of a research program in which the long term objective is to determine the underlying molecular mechanisms that pattern embryonic nervous systems. A series of studies are outlined in which I will test hypotheses on the embryonic origin of nerves, and the mechanisms by which Eph receptor and ephrin signaling guide migration of neural progenitor cells. These studies are to be carried out in sea urchin embryos - a model for studies in neurogenesis. My involvement with the sequencing and annotation of the sea urchin genome, experience with manipulation of gene expression, and a longstanding interest in neural development in urchin embryos makes this program unique. I propose support for a program to train students in modern developmental biology in which the precise roles of cell signalling molecules can be determined. These studies will contribute to fundamental questions of the role of cellular signaling in animal development. Sea urchins show close molecular kinship with vertebrates, yet they have a remarkably different body plan. Preliminary studies have revealed features that are shared with vertebrates providing an opportunity to contribute to our understanding of neural evolution. This is an established program of high-quality research that has been demonstrated to be a stimulating environment for research training. This research program will establish sea urchin embryos as a unique model for neural development with the potential to give new perspectives and insights to the function of Eph/ephrin signaling and evolution of neural development.