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Neural development

神经发育

基本信息

批准号：
2413-2009
负责人：
Burke, Robert
金额：
$ 4.37万
依托单位：
University of Victoria
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=513087
关键词：
Neural development

项目摘要

I propose continuation of a research program in which the long term objective is to determine the underlying molecular mechanisms that pattern embryonic nervous systems. A series of studies are outlined in which I will test hypotheses on the embryonic origin of nerves, and the mechanisms by which Eph receptor and ephrin signaling guide migration of neural progenitor cells. These studies are to be carried out in sea urchin embryos - a model for studies in neurogenesis. My involvement with the sequencing and annotation of the sea urchin genome, experience with manipulation of gene expression, and a longstanding interest in neural development in urchin embryos makes this program unique. I propose support for a program to train students in modern developmental biology in which the precise roles of cell signalling molecules can be determined. These studies will contribute to fundamental questions of the role of cellular signaling in animal development. Sea urchins show close molecular kinship with vertebrates, yet they have a remarkably different body plan. Preliminary studies have revealed features that are shared with vertebrates providing an opportunity to contribute to our understanding of neural evolution. This is an established program of high-quality research that has been demonstrated to be a stimulating environment for research training. This research program will establish sea urchin embryos as a unique model for neural development with the potential to give new perspectives and insights to the function of Eph/ephrin signaling and evolution of neural development.

我建议继续一项长期目标是确定胚胎神经系统模式的潜在分子机制的研究计划。在这些研究中，我将检验关于神经胚胎起源的假说，以及Eph受体和EPhin信号引导神经前体细胞迁移的机制。这些研究将在海胆胚胎中进行--这是一种研究神经发生的模型。我参与了海胆基因组的测序和注释，在基因表达操作方面的经验，以及对海胆胚胎神经发育的长期兴趣，使这个程序独一无二。我建议支持一项培训学生学习现代发育生物学的计划，在该计划中，可以确定细胞信号分子的确切作用。这些研究将有助于解决细胞信号在动物发育中的作用这一基本问题。海胆与脊椎动物显示出密切的分子亲缘关系，但它们的身体规划却截然不同。初步研究揭示了脊椎动物共有的特征，为我们理解神经进化提供了机会。这是一个既定的高质量研究计划，已被证明是一个激励研究培训的环境。这项研究计划将建立海胆胚胎作为神经发育的独特模型，有可能为Eph/EPhin信号转导的功能和神经发育的进化提供新的视角和见解。