Developmental Mechanisms of Neurogenesis

神经发生的发育机制

• 批准号: RGPIN-2016-03737
• 负责人: Burke, Robert
• 金额: $ 3.21万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629326
• 关键词: Developmental; Mechanisms; Neurogenesis

Most of what we know about the embryonic development of nervous systems comes from studies of flies or mice. As those studies revealed similar signaling systems and molecular pathways, it was proposed that nervous systems arose once, early in the history of multicellular animals. Subsequent studies in several types of invertebrates support this idea, but the striking diversity in how nervous systems develop makes it difficult to rationalize a single origin. A more refined explanation is that there has been independent evolution of the cellular organization in many groups and neurogenesis has drawn upon conserved signaling systems and molecular pathways in various ways as animals diversified. We lack the models necessary to test this hypothesis, as the molecular and cellular mechanisms underlying neurogenesis need to be carefully analyzed to make useful comparisons in groups of related animals.

我们对神经系统胚胎发育的了解大多来自对苍蝇或老鼠的研究。由于这些研究揭示了类似的信号系统和分子通路，因此有人提出神经系统在多细胞动物的早期历史中出现过一次。随后对几种无脊椎动物的研究支持了这一观点，但神经系统发育方式的惊人多样性使得很难合理化单一起源。一个更精确的解释是，在许多群体中，细胞组织都有独立的进化，随着动物的多样化，神经发生以各种方式利用保守的信号系统和分子通路。我们缺乏必要的模型来验证这一假设，因为神经发生的分子和细胞机制需要仔细分析，以便在相关动物组中进行有用的比较。