Organelle genetic systems in green algae

绿藻中的细胞器遗传系统

• 批准号: 9599-2009
• 负责人: Lee, Robert
• 金额: $ 2.11万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=474570
• 关键词: Organelle; genetic; systems; green; algae

Over the past several decades my laboratory has studied the evolution of genomes in green algae, the group from which land plants arose. The main focus of our work is on organelle genomes, i.e., those in mitochondria and chloroplasts, the sites of respiration and photosynthesis, respectively; the presence of genomes in mitochondria and chloroplasts is normally essential to the functioning of these organelles. The overriding theme of our efforts has been to document and explain the diversity of organelle genome features, like intact vs. fragmented; circular vs. linear, GC-rich vs. AT-rich, and compact vs. bloated (i.e., high vs. low fraction of the genome has a coding function). The proposed work for the next grant period focuses on three main activities: (1) testing the mutational-burden hypothesis as an explanation for the compactness variation in mitochondrial, chloroplast and nuclear genomes in selected unicellular green algal species;

在过去的几十年里，我的实验室研究了绿藻基因组的进化，陆地植物就是从绿藻进化而来的。我们的工作主要集中在细胞器基因组上，即线粒体和叶绿体中的基因组，分别是呼吸作用和光合作用的位置；线粒体和叶绿体中的基因组通常对这些细胞器的功能是必不可少的。我们努力的压倒一切的主题一直是记录和解释细胞器基因组特征的多样性，如完整与碎裂；环状与线形；富含GC与AT；以及紧凑与膨胀(即基因组的高与低部分具有编码功能)。下一批赠款期间的拟议工作集中在三个主要活动上：(1)检验突变-负担假说，以解释选定的单细胞绿藻物种线粒体、叶绿体和核基因组的紧凑性变化；