Energy-sensing regulation of cell-surface proteins

细胞表面蛋白的能量感应调节

• 批准号: 121624-2008
• 负责人: Blay, Jonathan
• 金额: $ 2.92万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=475563
• 关键词: Energy; sensing; regulation; cell; surface

Many aspects of a cell's behaviour are determined by factors in its immediate surroundings, a 'sphere of influence' that is referred to as the microenvironment. These specific influences may be signals provided by specialized proteins on the surfaces of adjacent cells, spatial information provided by the structural framework of the tissue (known as the extracellular matrix), or other molecules that diffuse freely in the extracellular fluid that normally bathes all cells (except at the outermost surfaces of the organism).

细胞行为的许多方面是由其直接环境中的因素决定的，即被称为微环境的“影响范围”。这些特定的影响可能是由邻近细胞表面的特定蛋白质提供的信号，由组织结构框架(称为细胞外基质)提供的空间信息，或其他在正常情况下沐浴所有细胞的细胞外液中自由扩散的分子(有机体最外表面除外)。