Mechanisms of epithelial morphogenesis in drosophila

果蝇上皮形态发生机制

• 批准号: 238938-2007
• 负责人: Nilson, Laura
• 金额: $ 2.33万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=479028
• 关键词: Mechanisms; epithelial; morphogenesis; drosophila

The aim of my research program is to understand how structures with different form and function arise as an organism develops. For example, an initially uniform sheet of cells, or epithelium, can take on a complex form as its individual cells change their shapes or undergo various movements. We use the ovary of the fruit fly, Drosophila melanogaster, as a simple experimental system for understanding what molecules inside the cell carry out these cellular behaviors. The follicular epithelium of the ovary, which surrounds each developing egg, starts out as a uniform sheet but, over time, two groups of cells in the tissue undergo a series of shape changes, creating folds in the tissue that go on to form two tubes of cells that project from the flat sheet.

我的研究计划的目的是了解不同形式和功能的结构是如何随着有机体的发育而产生的。例如，当单个细胞改变形状或经历各种运动时，最初统一的细胞片或上皮可以呈现复杂的形式。我们使用果蝇的卵巢作为一个简单的实验系统来了解细胞内的哪些分子执行这些细胞行为。围绕着每个发育中的卵子的卵巢滤泡上皮，一开始是一个统一的薄片，但随着时间的推移，组织中的两组细胞经历了一系列的形状变化，在组织中产生折叠，然后形成两管细胞，从扁平的薄片突出。