Robustness in developmental systems: how early development buffers genetic and environmental variation
发育系统的稳健性:早期发育如何缓冲遗传和环境变异
基本信息
- 批准号:238938-2013
- 负责人:
- 金额:$ 2.19万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2013
- 资助国家:加拿大
- 起止时间:2013-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is becoming clear that there exists abundant genetic and environmental variation that the developing organism must buffer against to produce a robust phenotype. Understanding the molecular genetic mechanisms that are involved in this buffering mechanism are necessary for a complete understanding of how shape, form, and proportion are generated during development. By integrating microfluidics technology, high throughput imaging, and artificial selection, my research program uses an innovative approach to studying in vivo how gene expression variation and function is regulated to produce a robust phenotype in spite of variation in the genotype, the environment, or both. This research will provide insight into how organisms develop robustly in the realistic context of a viable organism, and will improve our understanding of the factors affecting adaptation of organisms when their natural environment is perturbed.
越来越清楚的是,存在丰富的遗传和环境变异,发育中的生物体必须缓冲以产生稳健的表型。了解参与这种缓冲机制的分子遗传机制对于完全理解形状,形式和比例在发育过程中是如何产生的是必要的。通过整合微流体技术,高通量成像和人工选择,我的研究计划使用了一种创新的方法来研究体内基因表达变异和功能是如何调节的,以产生一个强大的表型,尽管在基因型,环境或两者的变化。这项研究将深入了解生物体如何在可行的生物体的现实背景下稳健地发展,并将提高我们对影响生物体适应的因素的理解,当它们的自然环境受到干扰时。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Nilson, Laura', 18)}}的其他基金
Regulation of transcriptional responses to intercellular signaling during development
发育过程中细胞间信号传导转录反应的调节
- 批准号:
RGPIN-2020-06100 - 财政年份:2022
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of transcriptional responses to intercellular signaling during development
发育过程中细胞间信号传导转录反应的调节
- 批准号:
RGPIN-2020-06100 - 财政年份:2021
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of transcriptional responses to intercellular signaling during development
发育过程中细胞间信号传导转录反应的调节
- 批准号:
RGPIN-2020-06100 - 财政年份:2020
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of cell-cell recognition during epithelial development
上皮发育过程中细胞间识别的调节
- 批准号:
RGPIN-2015-06401 - 财政年份:2019
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of cell-cell recognition during epithelial development
上皮发育过程中细胞间识别的调节
- 批准号:
RGPIN-2015-06401 - 财政年份:2018
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of cell-cell recognition during epithelial development
上皮发育过程中细胞间识别的调节
- 批准号:
RGPIN-2015-06401 - 财政年份:2017
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of cell-cell recognition during epithelial development
上皮发育过程中细胞间识别的调节
- 批准号:
RGPIN-2015-06401 - 财政年份:2016
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Regulation of cell-cell recognition during epithelial development
上皮发育过程中细胞间识别的调节
- 批准号:
RGPIN-2015-06401 - 财政年份:2015
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms of epithelial morphogenesis in drosophila
果蝇上皮形态发生机制
- 批准号:
238938-2007 - 财政年份:2011
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Canada Research Chair in Developmental Genetics
加拿大发育遗传学研究主席
- 批准号:
1000202889-2005 - 财政年份:2010
- 资助金额:
$ 2.19万 - 项目类别:
Canada Research Chairs
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