Translational control of hepatitis C virus: the role of NS5A

丙型肝炎病毒的转化控制：NS5A 的作用

• 批准号: 298484-2008
• 负责人: Liu, Qiang
• 金额: $ 2.09万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=480772
• 关键词: Translational; control; hepatitis; virus; role

The long-term goal of this research program is to study the molecular mechanisms of translational control of hepatitis C virus (HCV) protein. To understand the mechanisms by which HCV nonstructural protein-5A (NS5A) affects HCV protein translation is the short-term goal of this proposal. We plan to test the hypothesis that HCV NS5A protein regulates HCV protein translation through interaction with the 3'-untranslated region (UTR) and by modulating the phosphoinositide 3-kinase (PI3K)-Akt and the mitogen-activated protein kinase (MAPK) pathways. Research will focus on three objectives.

该研究计划的长期目标是研究丙型肝炎病毒(丙型肝炎病毒)蛋白翻译控制的分子机制。了解丙型肝炎病毒非结构蛋白-5A(NS5A)影响丙型肝炎病毒蛋白翻译的机制是本研究的短期目标。我们计划验证这一假设，即丙型肝炎病毒NS5A蛋白通过与3‘-非翻译区(UTR)相互作用，并通过调节磷脂酰肌醇3-激酶(PI3K)-Akt和丝裂原活化蛋白激酶(MAPK)途径来调节丙型肝炎病毒蛋白的翻译。研究将集中在三个目标上。