Translational control of hepatitis C virus: the role of NS5A

丙型肝炎病毒的转化控制：NS5A 的作用

• 批准号: 298484-2008
• 负责人: Liu, Qiang
• 金额: $ 2.09万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498037
• 关键词: Translational; control; hepatitis; virus; role

The long-term goal of this research program is to study the molecular mechanisms of translational control of hepatitis C virus (HCV) protein. To understand the mechanisms by which HCV nonstructural protein-5A (NS5A) affects HCV protein translation is the short-term goal of this proposal. We plan to test the hypothesis that HCV NS5A protein regulates HCV protein translation through interaction with the 3'-untranslated region (UTR) and by modulating the phosphoinositide 3-kinase (PI3K)-Akt and the mitogen-activated protein kinase (MAPK) pathways. Research will focus on three objectives.

本研究计划的长期目标是研究丙型肝炎病毒（HCV）蛋白翻译控制的分子机制。了解HCV非结构蛋白5A（NS 5A）影响HCV蛋白翻译的机制是本研究的近期目标。我们计划验证HCV NS 5A蛋白通过与3 '-非翻译区（UTR）相互作用以及通过调节磷酸肌醇3-激酶（PI 3 K）-Akt和丝裂原活化蛋白激酶（MAPK）途径来调节HCV蛋白翻译的假设。研究将侧重于三个目标。