Mentoring Translational Research in HIV

指导艾滋病毒转化研究

• 批准号: 9347608
• 负责人: David Mitchell Smith
• 金额: $ 12.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9347608
• 关键词: AIDS prevention; Adult; Antibodies; Antibody Repertoire; Award; Blood specimen; CD4 Positive T Lymphocytes; Centers for Disease Control and Prevention (U.S.); Chronic; Clinical; Cytomegalovirus; DNA; Data; Databases; Epidemiologic Methods; Funding; Future; Genetic Transcription; Goals; Grant; HIV; HIV vaccine; HIV-1; HIV-associated neurocognitive disorder; Hepatitis C; Individual; Infection; Interferons; Interleukin-10; Investigation; Length; Measures; Mentors; Messenger RNA; Methods; Molecular; Molecular Epidemiology; Molecular Virology; Monoclonal Antibodies; Neurocognition; Neurocognitive Deficit; New York City; Oral; Participant; Pathogenesis; Peripheral Blood Mononuclear Cell; Persons; Phylogenetic Analysis; Preventive Intervention; Process; Publications; RNA; Regimen; Research; Research Design; Research Personnel; Research Project Grants; Risk; Seminal Plasma; Structure; Techniques; Technology; Time; Training; Training Programs; Training Support; Translational Research; Viral; Work; Writing; career; co-infection; cohort; deep sequencing; improved; novel; patient oriented; professor; protocol development; public health intervention; success; transmission process; virology

Project Summary This application is a proposed renewal of Dr. Davey Smith's K24 grant entitled `Mentoring Translational Research in HIV'. This grant supported the training of over 30 trainees and 80 publications to date. While significant progress in HIV research continues to be made, it is not likely that a safe and effective cure or vaccine for HIV will be developed soon. The success of these goals will depend on future HIV researchers, many of whom are likely to be trained in the next five years. The goal of this K24 proposal is to provide Dr. Smith with sufficient support to mentor trainees in state-of-the-art translational and patient oriented HIV research and to expand his involvement in UCSD's wide array of training programs. This application is built upon funded and ongoing research projects, where the mentee is the primary leader and is trained in every aspect of study design, execution, analyses, results interpretation and publication. The presented studies provide opportunities for in-depth mentoring as well as investigation into important and open scientific questions in HIV pathogenesis. These goals will be met in the following three aims with a core group of junior and senior trainees. SPECIFIC AIM 1: To determine how co-infections impact HIV pathogenesis. SPECIFIC AIM 2: To develop and validate new molecular virology technology. SPECIFIC AIM 3: To use molecular epidemiologic methods to inform HIV prevention.

项目概要 本申请是 Davey Smith 博士的 K24 补助金的拟议更新，题为“指导转化研究” 在艾滋病毒中”。迄今为止，这笔赠款已支持 30 多名学员的培训和 80 种出版物。虽然意义重大 尽管艾滋病毒研究不断取得进展，但不太可能找到安全有效的艾滋病毒治疗方法或疫苗 很快就会被开发出来。这些目标的成功将取决于未来的艾滋病毒研究人员，其中许多人是 可能会在未来五年内接受培训。 这项 K24 提案的目标是为史密斯博士提供足够的支持，以指导学员掌握最先进的技术 转化和以患者为导向的艾滋病毒研究，并扩大他对加州大学圣地亚哥分校广泛培训的参与 程序。该应用程序建立在受资助和正在进行的研究项目的基础上，其中受训者是主要的 领导者，并在研究设计、执行、分析、结果解释和出版的各个方面接受过培训。 所提出的研究为深入指导以及调查重要和重要的问题提供了机会。 HIV发病机制中的开放科学问题。这些目标将通过以下三个核心目标来实现 初级和高级学员组。 具体目标 1：确定合并感染如何影响 HIV 发病机制。 具体目标 2：开发和验证新的分子病毒学技术。 具体目标 3：利用分子流行病学方法为 HIV 预防提供信息。