Multi-modal calibration techniques for quantitative brain imaging

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This research program aims to develop new imaging methods that allow more detailed and accurate measurements of different physiological processes in the brain. These techniques will involve a combination of magnetic resonance imaging and new optical imaging methods, where highly penetrating low energy light is projected through the head. The data provided by these two techniques can be integrated using new physical models of the magnetic and light propagation properties of brain tissue to produce more accurate measures of the brain's ability to deliver and use oxygen. Such measurements will provide important information on changes in brain function during aging and diseases such as Alzheimer's and other neurodegenerative conditions.