Multi-modal calibration techniques for quantitative brain imaging

定量脑成像的多模态校准技术

• 批准号: 355583-2010
• 负责人: Hoge, Richard
• 金额: $ 2.11万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549772
• 关键词: Multi; modal; calibration; techniques; quantitative

This research program aims to develop new imaging methods that allow more detailed and accurate measurements of different physiological processes in the brain. These techniques will involve a combination of magnetic resonance imaging and new optical imaging methods, where highly penetrating low energy light is projected through the head. The data provided by these two techniques can be integrated using new physical models of the magnetic and light propagation properties of brain tissue to produce more accurate measures of the brain's ability to deliver and use oxygen. Such measurements will provide important information on changes in brain function during aging and diseases such as Alzheimer's and other neurodegenerative conditions.

这项研究计划旨在开发新的成像方法，允许对大脑中不同的生理过程进行更详细和准确的测量。这些技术将涉及磁共振成像和新的光学成像方法的组合，在这种方法中，高穿透性的低能量光通过头部投射。这两种技术提供的数据可以使用新的脑组织磁光传播特性的物理模型进行整合，从而更准确地衡量大脑输送和利用氧气的能力。这样的测量将提供有关衰老期间大脑功能变化以及阿尔茨海默氏症和其他神经退行性疾病等疾病的重要信息。