Chondrocyte transduction of osmotic challenge: the role of integrin alpha 1 in ion flux and cytoskeletal activation

渗透挑战的软骨细胞转导：整合素 α1 在离子流和细胞骨架激活中的作用

• 批准号: 371276-2010
• 负责人: Clark, Andrea
• 金额: $ 1.75万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=483520
• 关键词: Chondrocyte; transduction; osmotic; challenge; role

Articular cartilage is a soft tissue lining the ends of bones in articulating joints such as the knee. This tissue is maintained by cells called chondrocytes. Cartilage is charged and hydrated and thus the compression and relaxation of this tissue during normal movement results in complex alterations in the environment immediately surrounding the chondrocytes. For example, cartilage compression results in a loss of fluid out of the tissue and a concentration of the large 'bottle brush' molecules (proteoglycans) that hold negative charges in

关节软骨是一种软组织，在膝关节等关节的骨骼末端形成衬里。这种组织由称为软骨细胞的细胞维持。软骨被带电和水合，因此，在正常运动过程中，软骨组织的压缩和松弛导致软骨细胞周围环境的复杂变化。例如，软骨受压会导致组织外液体的流失，并导致体内携带负电荷的大分子(蛋白多糖)的浓度增加。