Signal transduction mechanisms of the chondrocyte

软骨细胞的信号转导机制

• 批准号: RGPIN-2017-04531
• 负责人: Clark, Andrea
• 金额: $ 1.82万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630169
• 关键词: Signal; transduction; mechanisms; chondrocyte

Articular cartilage is a soft tissue covering the surfaces of bones within synovial joints. Cartilage is compressed and relaxed during joint motion leading to changes in osmotic stress as fluid is extruded and then imbibed by the proteoglycan rich matrix. As the only cells of cartilage, chondrocytes play a critical role in maintaining the extracellular matrix. Chondrocytes are sensitive to mechanical and chemical changes in their locale and reciprocate with a variety of biological responses.

关节软骨是覆盖在滑膜关节骨表面的软组织。在关节运动过程中，软骨被压缩和放松，流体被挤压，然后被富含蛋白多糖的基质吸收，从而导致渗透应力的变化。软骨细胞作为软骨的唯一细胞，在维持细胞外基质中起着至关重要的作用。软骨细胞对其所在位置的机械和化学变化很敏感，并与各种生物反应相互作用。