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Hydrogel-based microfluidic cell culture system for controlled drug dosage effects

Hydrogel-based microfluidic cell culture system for controlled drug dosage effects
基于水凝胶的微流体细胞培养系统,用于控制药物剂量效应
批准号:
398613-2011
负责人:
Cheung, Karen
金额:
$0.7万
依托单位国家:
加拿大
项目类别:
Collaborative Health Research Projects
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-01-01 至 2012-12-31

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英文摘要
OBJECTIVE: This project will develop a microfluidic system to culture, characterize, image, and screen cells within a single automated, portable platform, with large potential impact to improve cell-based drug screening. BACKGROUND: The 2-D monolayer-based method of cell culture is well established in molecular and cell biology. Recently, there has been increased interest in 3-D cell culture, in which cells are embedded in a material that mimics the ECM. Interaction between cells and the ECM in vivo regulates differentiation, migration, and many other functions. As a cancer model, the tissue culture environment can have a dramatic influence on cell behaviour, such as modified morphology, gene expression, and proliferation. This
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