Microfluidic systems for 3D cell culture and micro tissue constructs

用于 3D 细胞培养和微组织构建的微流体系统

• 批准号: RGPIN-2015-04324
• 负责人: Cheung, Karen
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589730
• 关键词: Microfluidic; systems; 3D; cell; culture

This research program focuses on the development of methods to create three dimensional (3D) microscale tissue models for tissue engineering and drug screening applications. We will use microfluidic systems to generate tissue models comprising elements of the extracellular matrix (ECM) which will support the embedded cells. We will also investigate hydrodynamics of inkjet printing of cell suspensions in order to understand the phenomena and parameters which contribute to unreliable cell dispensing during tissue patterning. We will use particle image velocimetry and high-speed imaging to characterize the flow field inside inkjet nozzles during the printing process.

该研究计划的重点是开发用于组织工程和药物筛选应用的三维（3D）微尺度组织模型的方法。我们将使用微流体系统来生成组织模型，该组织模型包括将支持嵌入的细胞的细胞外基质（ECM）的元素。我们还将研究细胞悬浮液的喷墨打印的流体动力学，以了解在组织图案化过程中导致不可靠的细胞分配的现象和参数。我们将使用粒子图像测速仪和高速成像来表征打印过程中喷墨喷嘴内部的流场。