Insulin assay through high performance liquid chromatography

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The direction of my NSERC supported research is to focus on insulin drug delivery using new and novel approaches in encapsulation methods and materials. The research is built around three main objectives, interrelated through insulin delivery. The first objective is to achieve long term (days and weeks) delivery of low levels of insulin from microparticles, then ultimately from microparticles embedded within natural polymer foams or films. The long-term goal is to design bioactive dressings for burn and wound injuries. The second objective is to encapsulate human islet cells together with fabricated cell matrix proteins within a polymeric particle. Canada is a leader in islet implantation therapies, and this initiative can contribute to the advancement of diabetes treatment through enhanced implanted islet viability and glucose-responsive insulin production. The third objective is to chemically modify natural polymers, providing novel biomaterials that do not exist in nature, or have not been previously synthesized. The intent is to use the new biomaterials for oral insulin delivery and other drug delivery applications.