Insulin assay through high performance liquid chromatography

我的NSERC支持的研究的方向是使用新的和新的方法在胶囊方法和材料上传递胰岛素药物。这项研究围绕三个主要目标展开，这三个目标通过胰岛素传递相互关联。第一个目标是实现长期(几天和几周)从微粒中释放低水平的胰岛素，然后最终从嵌入天然聚合物泡沫或薄膜中的微粒中释放。长期目标是设计用于烧伤和伤口损伤的生物活性敷料。第二个目标是将人胰岛细胞与制造的细胞基质蛋白一起包裹在一个聚合物颗粒中。加拿大在胰岛移植疗法方面处于领先地位，这一倡议可以通过提高移植胰岛的存活率和葡萄糖反应性胰岛素的产生来促进糖尿病治疗的进步。第三个目标是对天然聚合物进行化学修饰，提供自然界中不存在的或以前从未合成的新型生物材料。其目的是将新的生物材料用于口服胰岛素输送和其他药物输送应用。

The direction of my NSERC supported research is to focus on insulin drug delivery using new and novel approaches in encapsulation methods and materials. The research is built around three main objectives, interrelated through insulin delivery. The first objective is to achieve long term (days and weeks) delivery of low levels of insulin from microparticles, then ultimately from microparticles embedded within natural polymer foams or films. The long-term goal is to design bioactive dressings for burn and wound injuries. The second objective is to encapsulate human islet cells together with fabricated cell matrix proteins within a polymeric particle. Canada is a leader in islet implantation therapies, and this initiative can contribute to the advancement of diabetes treatment through enhanced implanted islet viability and glucose-responsive insulin production. The third objective is to chemically modify natural polymers, providing novel biomaterials that do not exist in nature, or have not been previously synthesized. The intent is to use the new biomaterials for oral insulin delivery and other drug delivery applications.