Insulin assay through high performance liquid chromatography

通过高效液相色谱法测定胰岛素

• 批准号: 422838-2012
• 负责人: Neufeld, Ronald
• 金额: $ 3.73万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=495855
• 关键词: Insulin; assay; through; performance; liquid

The direction of my NSERC supported research is to focus on insulin drug delivery using new and novel approaches in encapsulation methods and materials. The research is built around three main objectives, interrelated through insulin delivery. The first objective is to achieve long term (days and weeks) delivery of low levels of insulin from microparticles, then ultimately from microparticles embedded within natural polymer foams or films. The long-term goal is to design bioactive dressings for burn and wound injuries. The second objective is to encapsulate human islet cells together with fabricated cell matrix proteins within a polymeric particle. Canada is a leader in islet implantation therapies, and this initiative can contribute to the advancement of diabetes treatment through enhanced implanted islet viability and glucose-responsive insulin production. The third objective is to chemically modify natural polymers, providing novel biomaterials that do not exist in nature, or have not been previously synthesized. The intent is to use the new biomaterials for oral insulin delivery and other drug delivery applications.

我的NSERC支持的研究方向是集中在胰岛素药物输送使用新的和新颖的方法在封装方法和材料。该研究围绕三个主要目标展开，并通过胰岛素输送相互关联。第一个目标是实现从微颗粒中长期（数天和数周）递送低水平胰岛素，然后最终从嵌入天然聚合物泡沫或薄膜中的微颗粒中递送。长期目标是为烧伤和伤口设计生物活性敷料。第二个目标是将人类胰岛细胞与合成的细胞基质蛋白一起包裹在聚合物颗粒中。加拿大在胰岛植入治疗方面处于领先地位，这一举措可以通过提高植入胰岛的活力和葡萄糖反应性胰岛素的产生来促进糖尿病治疗的进步。第三个目标是化学修饰天然聚合物，提供自然界中不存在或以前未合成的新型生物材料。目的是将新的生物材料用于口服胰岛素输送和其他药物输送应用。