The role of cardiac tissue biomechanical characteristics on electrical, structural, and arrhythmic properties

心脏组织生物力学特性对电、结构和心律失常特性的作用

• 批准号: 355537-2008
• 负责人: Comtois, Philippe
• 金额: $ 1.41万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=503553
• 关键词: role; cardiac; tissue; biomechanical; characteristics

The heart is composed of electrically active cells. The cell is mechanically coupled by an elastic matrix. There is a functional link between mechanical and electrical actions. This link can change under pathological conditions when the tissue is stretched. The dispersion of stretch throughout the tissue can differ. Electrical properties can change with stretch through activation of special electrical channels. High level of stretch even induces cell death and fibrosis. Increasing fibrosis results in the formation of obstacles to electrical propagation. The changes in electrical properties and the formation of obstacles can both play an important role in cardiac arrhythmias. New tools to understand the effects of tissue stretch on arrhythmias are needed. The main objective of this project is to build a realistic model of the effects of stretch and fibrosis on electrical activity of cardiac tissue. However, there is limited data and tools to detail these effects.

心脏是由电活性细胞组成的。该单元由弹性矩阵进行机械耦合。机械作用和电气作用之间存在着功能上的联系。在病理条件下，当组织被拉伸时，这种联系会发生变化。拉伸在整个组织中的分散程度可能不同。通过激活特殊的电通道，电性能可以随着拉伸而改变。高水平的拉伸甚至诱导细胞死亡和纤维化。纤维化的增加导致电传播障碍的形成。电学性质的改变和障碍的形成都在心律失常中起重要作用。需要新的工具来了解组织拉伸对心律失常的影响。本项目的主要目的是建立一个真实的模型，研究拉伸和纤维化对心脏组织电活动的影响。然而，详细描述这些影响的数据和工具有限。