The universal genetic tool kit for in vivo neuron modulation, molecular profiling, and connectivity mapping

当代神经科学的一个根本挑战是解决神经元的特性如何与特定的行为和生理过程相关。为了解决这个问题，我们必须系统地研究神经元的一系列功能特性，包括它们的形状、基因表达、连通性、电生理学，最后是它们在行为中的作用。当目标是解决神经系统在损伤和疾病中的动态变化时，这就变得特别有价值。

A fundamental challenge for contemporary neuroscience is to address how the properties of neurons relate to specific behaviors and physiological processes. To address this question, one must systematically examine a range of functional properties of neurons, including their shape, gene expression, connectivity, electrophysiology, and finally their role in behavior. This becomes particularly valuable when the objective is to address the dynamic changes of the nerve system in injury and disease.