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PrP N-terminal sequences and biological endpoints in Prion and Alzheimer's Disease

PrP N-terminal sequences and biological endpoints in Prion and Alzheimer's Disease
PrP N 末端序列和朊病毒和阿尔茨海默病的生物学终点
批准号:
255928
负责人:
Westaway David
金额:
$48.79万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-03-01 至 2017-03-01

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中文摘要
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英文摘要
Prion diseases such as mad cow are caused by a normal component of brain cells, the cellular prion protein, "PrPC", folding into the wrong 3D shape. Interestingly we and others have described that PrPC participates in early chemical events in a different
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Diverse disease-associated forms of tau; molecular cell biology and relationships to pathogenesis.
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    420911
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  • 资助金额:
    $64.37万
  • 财政年份:
    2020
  • 负责人:
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Age-dependent development of a primary Tauopathy: the gut/brain axis and biogenesis of Tau strains
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    398861
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  • 资助金额:
    $32.78万
  • 财政年份:
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  • 依托单位:
Visualizing stochastic protein misfolding to understand the origins of sporadic Tauopathies
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    347409
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  • 负责人:
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  • 依托单位:
海外基金