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Computational models of eukaryotic cell polarization/motility

Computational models of eukaryotic cell polarization/motility
真核细胞极化/运动的计算模型
批准号:
41870-2012
负责人:
EdelsteinKeshet, Leah
金额:
$5.1万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31

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中文摘要
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英文摘要
Cell motility is of fundamental importance in development, immune surveillance, and wound healing in eukaryotes. It also plays a nefarious role in metastasis in cancer. The actin cytoskeleton, which shapes the cell and drives protrusive motility is regulated by layers of signaling pathways. A focal question that motivates my research is how spatio-temporal dynamics of such signaling molecules are coordinated, and how these then combine to produce directed cell motility. My work includes derivation and analysis of mathematical models (both detailed and simplified for analysis), simulations of the time behaviour and spatial distribution of intracellular signaling molecules, and experimental validation (with experimental collaborators).
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Models and computation of intracellular signaling in single and collective cell migration
  • 批准号:
    RGPIN-2020-04067
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $5.87万
  • 财政年份:
    2022
  • 负责人:
    EdelsteinKeshet, Leah
  • 依托单位:
Models and computation of intracellular signaling in single and collective cell migration
  • 批准号:
    RGPIN-2020-04067
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $5.87万
  • 财政年份:
    2021
  • 负责人:
    EdelsteinKeshet, Leah
  • 依托单位:
Models and computation of intracellular signaling in single and collective cell migration
  • 批准号:
    RGPIN-2020-04067
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $5.87万
  • 财政年份:
    2020
  • 负责人:
    EdelsteinKeshet, Leah
  • 依托单位:
Computational models of eukaryotic cell polarization/motility
  • 批准号:
    41870-2012
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $5.1万
  • 财政年份:
    2019
  • 负责人:
    EdelsteinKeshet, Leah
  • 依托单位:
国内基金
海外基金
Scalable Learning and Optimization: High-dimensional Models and Online Decision-Making Strategies for Big Data Analysis
河北南部地区灰霾的来源和形成机制研究
  • 批准号:
    41105105
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    25.0万元
  • 批准年份:
    2011
  • 负责人:
    王丽涛
  • 依托单位:
保险风险模型、投资组合及相关课题研究
  • 批准号:
    10971157
  • 项目类别:
    面上项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2009
  • 负责人:
    胡亦钧
  • 依托单位:
RKTG对ERK信号通路的调控和肿瘤生成的影响