Mathematical models of actin in cell motility and of swarms/schools in social aggregation

细胞运动中肌动蛋白和社会聚集中群体/学校的数学模型

• 批准号: 41870-2007
• 负责人: EdelsteinKeshet, Leah
• 金额: $ 2.55万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=421243
• 关键词: Mathematical; models; actin; cell; motility

The cytoskeleton, and its major biopolymer, actin are responsible for the shape, motility, and many aspects of animal cell function. In recent years, my group has modelled how actin turnover contributes to protrusive cell motility, and how signalling components (Rho family GTPases Cdc42, Rac, Rho, and phosphoinositides PIP, PIP2, PIP3), regulate actin dynamics. In response to a graded stimulus, our "model cell" produces stable internal profiles of GTPases and PIs, and initiates persistent motility, consistent with the biology. (We showed that GTPases work as a spatial switch, PIs filter noise, and define the front vs. back. Relatively fast PI diffusion also leads to selection of a unique pattern of Rho GTPase distribution from a collection of possible patterns). We also assembled preliminary 2D simulations of a crawling cell.

细胞骨架及其主要的生物聚合物肌动蛋白负责动物细胞的形状、运动和许多方面的功能。近年来，我的团队已经建立了肌动蛋白转换如何促进突出细胞运动的模型，以及信号成分（Rho家族GTPases Cdc42、Rac、Rho和磷酸肌苷PIP、PIP2、PIP3）如何调节肌动蛋白动力学。在对分级刺激的反应中，我们的“模型细胞”产生了稳定的gtp酶和pi的内部轮廓，并启动了与生物学一致的持续运动。(我们展示了GTPases作为一个空间开关，pi过滤噪声，并定义正面和背面。相对快速的PI扩散也导致从可能的模式集合中选择一个独特的Rho GTPase分布模式)。我们还组装了爬行细胞的初步二维模拟。