Computational models of eukaryotic cell polarization/motility

真核细胞极化/运动的计算模型

• 批准号: 41870-2012
• 负责人: EdelsteinKeshet, Leah
• 金额: $ 5.1万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521598
• 关键词: Computational; models; eukaryotic; cell; polarization

Cell motility is of fundamental importance in development, immune surveillance, and wound healing in eukaryotes. It also plays a nefarious role in metastasis in cancer. The actin cytoskeleton, which shapes the cell and drives protrusive motility is regulated by layers of signaling pathways. A focal question that motivates my research is how spatio-temporal dynamics of such signaling molecules are coordinated, and how these then combine to produce directed cell motility. My work includes derivation and analysis of mathematical models (both detailed and simplified for analysis), simulations of the time behaviour and spatial distribution of intracellular signaling molecules, and experimental validation (with experimental collaborators).

细胞运动在真核生物的发育、免疫监视和伤口愈合中具有重要的基础作用。它在癌症的转移中也起着邪恶的作用。肌动蛋白细胞骨架，塑造细胞和驱动突出运动是由信号通路层调节。激发我研究的一个焦点问题是这些信号分子的时空动力学是如何协调的，以及这些分子如何结合起来产生定向细胞运动。我的工作包括推导和分析数学模型（包括详细的和简化的分析），模拟细胞内信号分子的时间行为和空间分布，以及实验验证（与实验合作者）。