Origins of variation in muscle mitochondrial metabolism

肌肉线粒体代谢变异的起源

• 批准号: 170572-2012
• 负责人: Moyes, Christopher
• 金额: $ 4.74万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=513889
• 关键词: Origins; variation; muscle; mitochondrial; metabolism

My program explores the origins and consequences of variation in muscle energy production: how muscle metabolism is remodelled when needed and how differences in metabolic machinery arise between tissues and animals as a consequence of evolution and development. By comparing and contrasting models and experimental approaches, we hope to distinguish between regulatory pathways that are broadly conserved among animals and those that are responsible for unique features of specific tissues and animals.

我的计划探讨了肌肉能量产生变化的起源和后果：肌肉代谢在需要时如何重塑，以及组织和动物之间的代谢机制如何因进化和发展而产生差异。通过比较和对比模型和实验方法，我们希望区分在动物中广泛保守的调节途径和那些负责特定组织和动物独特特征的调节途径。