Origins of variation in mitochondrial metabolism

线粒体代谢变异的起源

• 批准号: RGPIN-2017-04551
• 负责人: Moyes, Christopher
• 金额: $ 2.84万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630624
• 关键词: Origins; variation; mitochondrial; metabolism

These studies help define the cellular and genetic pathways that are the underpinnings of diversity seen in nature, giving insight into the evolutionary origins of pathways known to be vital to our own metabolism. This work is done primarily to understand evolutionary origins of diversity in genes critical in determining the metabolic physiology of animals, but the results have direct relevance to the many human diseases with etiologies that are intertwined with energy metabolism, such as diabetes and ischemia/reperfusion.

这些研究有助于定义细胞和遗传途径，这些途径是自然界中多样性的基础，使我们能够深入了解已知对我们自身代谢至关重要的途径的进化起源。这项工作主要是为了了解决定动物代谢生理学的关键基因多样性的进化起源，但结果与许多人类疾病有直接关系，这些疾病的病因与能量代谢有关，如糖尿病和缺血/再灌注。