Probing the spatiotemporal dynamics of immune cell surface receptors

探索免疫细胞表面受体的时空动态

• 批准号: 288180-2009
• 负责人: Coombs, Daniel
• 金额: $ 4.92万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514689
• 关键词: Probing; spatiotemporal; dynamics; immune; cell

Cells of the immune system, such as T and B lymphocytes, sense their environment using an array of specialized surface receptors. Upon binding a suitable foreign substance, these receptors generate intracellular signals, allowing the cell to respond appropriately to a given stimulus. During cellular stimulation, surface receptors (such as the T and B cell receptors - TCR and BCR) are commonly observed to reorganize their movement and location. For example, TCR and BCR are observed to form sub-micrometer clusters on the cell surface. Our understanding of how receptor signaling leads to changes in receptor motion, and how these dynamic changes affect subsequent signaling, is a key part of our knowledge of the processes governing lymphocyte activation.

免疫系统的细胞，如T淋巴细胞和B淋巴细胞，通过一系列特殊的表面受体来感知环境。在与合适的外来物质结合后，这些受体产生细胞内信号，使细胞对给定的刺激作出适当的反应。在细胞刺激过程中，通常观察到表面受体（如T细胞和B细胞受体- TCR和BCR）重组其运动和位置。例如，观察到TCR和BCR在细胞表面形成亚微米级的团簇。我们对受体信号传导如何导致受体运动变化，以及这些动态变化如何影响后续信号传导的理解，是我们了解淋巴细胞活化过程的关键部分。