Mobility, organization and signalling of immune cell surface receptors

免疫细胞表面受体的移动性、组织和信号传导

• 批准号: RGPIN-2015-04611
• 负责人: Coombs, Daniel
• 金额: $ 3.79万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628815
• 关键词: Mobility; organization; signalling; immune; cell

B cells are an essential part of the adaptive immune response. In vivo, B cells can become activated (leading to proliferation and secretion of antibodies that bind to and neutralize invading pathogens) after binding specific antigens with their B cell receptors (BCR). B cell surface receptors are known to spatially organize themselves during antigenic signal detection. Therefore, in order to obtain a proper understanding of B cell activation, we need to study the motion of surface molecules such as BCR and relate their motion to the biochemical reactions within the cell that lead to cell activation.

B细胞是适应性免疫应答的重要组成部分。在体内，B细胞可以在将特异性抗原与其B细胞受体（BCR）结合后变得活化（导致增殖和分泌结合并中和入侵病原体的抗体）。已知B细胞表面受体在抗原信号检测期间在空间上组织它们自己。因此，为了获得对B细胞活化的正确理解，我们需要研究表面分子如BCR的运动，并将它们的运动与细胞内导致细胞活化的生化反应联系起来。