Mobility, organization and signalling of immune cell surface receptors
免疫细胞表面受体的移动性、组织和信号传导
基本信息
- 批准号:RGPIN-2015-04611
- 负责人:
- 金额:$ 3.79万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
B cells are an essential part of the adaptive immune response. In vivo, B cells can become activated (leading to proliferation and secretion of antibodies that bind to and neutralize invading pathogens) after binding specific antigens with their B cell receptors (BCR). B cell surface receptors are known to spatially organize themselves during antigenic signal detection. Therefore, in order to obtain a proper understanding of B cell activation, we need to study the motion of surface molecules such as BCR and relate their motion to the biochemical reactions within the cell that lead to cell activation.
B细胞是适应性免疫应答的重要组成部分。在体内,B细胞可以在将特异性抗原与其B细胞受体(BCR)结合后变得活化(导致增殖和分泌结合并中和入侵病原体的抗体)。已知B细胞表面受体在抗原信号检测期间在空间上组织它们自己。因此,为了获得对B细胞活化的正确理解,我们需要研究表面分子如BCR的运动,并将它们的运动与细胞内导致细胞活化的生化反应联系起来。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Coombs, Daniel其他文献
Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults.
- DOI:
10.1186/s12879-023-08950-1 - 发表时间:
2024-01-15 - 期刊:
- 影响因子:3.7
- 作者:
Silverberg, Sarah L.;Shulha, Hennady P.;Mcmillan, Brynn;He, Guanyuhui;Lee, Amy;Marquez, Ana Citlali;Bartlett, Sofia R.;Gill, Vivek;Abu-Raya, Bahaa;Bettinger, Julie A.;Cabrera, Adriana;Coombs, Daniel;Gantt, Soren;Goldfarb, David M.;Sauve, Laura;Krajden, Mel;Morshed, Muhammad;Sekirov, Inna;Jassem, Agatha N.;Sadarangani, Manish - 通讯作者:
Sadarangani, Manish
Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study
- DOI:
10.1016/s2468-2667(18)30044-6 - 发表时间:
2018-05-01 - 期刊:
- 影响因子:50
- 作者:
Irvine, Michael A.;Buxton, Jane A.;Coombs, Daniel - 通讯作者:
Coombs, Daniel
On the duration of the period between exposure to HIV and detectable infection
- DOI:
10.1016/j.epidem.2017.03.002 - 发表时间:
2017-09-01 - 期刊:
- 影响因子:3.8
- 作者:
Konrad, Bernhard P.;Taylor, Darlene;Coombs, Daniel - 通讯作者:
Coombs, Daniel
Analysis of membrane-localized binding kinetics with FRAP
- DOI:
10.1007/s00249-008-0286-z - 发表时间:
2008-06-01 - 期刊:
- 影响因子:2
- 作者:
Dushek, Omer;Das, Raibatak;Coombs, Daniel - 通讯作者:
Coombs, Daniel
Diffusion analysis of single particle trajectories in a Bayesian nonparametrics framework
- DOI:
10.1088/1478-3975/ab64b3 - 发表时间:
2020-03-01 - 期刊:
- 影响因子:2
- 作者:
Falcao, Rebeca Cardim;Coombs, Daniel - 通讯作者:
Coombs, Daniel
Coombs, Daniel的其他文献
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{{ truncateString('Coombs, Daniel', 18)}}的其他基金
Super-resolution imaging, single cell analysis, and modelling approaches applied to the study of immune cell signaling and behaviour
超分辨率成像、单细胞分析和建模方法应用于免疫细胞信号传导和行为的研究
- 批准号:
RGPIN-2020-04820 - 财政年份:2022
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Super-resolution imaging, single cell analysis, and modelling approaches applied to the study of immune cell signaling and behaviour
超分辨率成像、单细胞分析和建模方法应用于免疫细胞信号传导和行为的研究
- 批准号:
RGPIN-2020-04820 - 财政年份:2021
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Super-resolution imaging, single cell analysis, and modelling approaches applied to the study of immune cell signaling and behaviour
超分辨率成像、单细胞分析和建模方法应用于免疫细胞信号传导和行为的研究
- 批准号:
RGPIN-2020-04820 - 财政年份:2020
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Mobility, organization and signalling of immune cell surface receptors
免疫细胞表面受体的移动性、组织和信号传导
- 批准号:
RGPIN-2015-04611 - 财政年份:2019
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Mobility, organization and signalling of immune cell surface receptors
免疫细胞表面受体的移动性、组织和信号传导
- 批准号:
RGPIN-2015-04611 - 财政年份:2018
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Mobility, organization and signalling of immune cell surface receptors
免疫细胞表面受体的移动性、组织和信号传导
- 批准号:
RGPIN-2015-04611 - 财政年份:2016
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Mobility, organization and signalling of immune cell surface receptors
免疫细胞表面受体的移动性、组织和信号传导
- 批准号:
RGPIN-2015-04611 - 财政年份:2015
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Probing the spatiotemporal dynamics of immune cell surface receptors
探索免疫细胞表面受体的时空动态
- 批准号:
288180-2009 - 财政年份:2013
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Probing the spatiotemporal dynamics of immune cell surface receptors
探索免疫细胞表面受体的时空动态
- 批准号:
288180-2009 - 财政年份:2012
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
Probing the spatiotemporal dynamics of immune cell surface receptors
探索免疫细胞表面受体的时空动态
- 批准号:
288180-2009 - 财政年份:2011
- 资助金额:
$ 3.79万 - 项目类别:
Discovery Grants Program - Individual
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功能有机配体新颖设计与有机金属超分子导向组装
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Mobility, organization and signalling of immune cell surface receptors
免疫细胞表面受体的移动性、组织和信号传导
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免疫细胞表面受体的移动性、组织和信号传导
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