Probing the spatiotemporal dynamics of immune cell surface receptors

探索免疫细胞表面受体的时空动态

• 批准号: 288180-2009
• 负责人: Coombs, Daniel
• 金额: $ 4.92万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525718
• 关键词: Probing; spatiotemporal; dynamics; immune; cell

Cells of the immune system, such as T and B lymphocytes, sense their environment using an array of specialized surface receptors. Upon binding a suitable foreign substance, these receptors generate intracellular signals, allowing the cell to respond appropriately to a given stimulus. During cellular stimulation, surface receptors (such as the T and B cell receptors - TCR and BCR) are commonly observed to reorganize their movement and location. For example, TCR and BCR are observed to form sub-micrometer clusters on the cell surface. Our understanding of how receptor signaling leads to changes in receptor motion, and how these dynamic changes affect subsequent signaling, is a key part of our knowledge of the processes governing lymphocyte activation.

免疫系统的细胞（例如T和B淋巴细胞）使用一系列专门的表面受体来感知其环境。结合合适的异物后，这些受体会产生细胞内信号，从而使细胞对给定的刺激做出适当反应。在细胞刺激期间，通常观察到表面受体（例如T和B细胞受体-TCR和BCR）重新组织其运动和位置。例如，观察到TCR和BCR在细胞表面形成亚微米簇。我们对受体信号如何导致受体运动的变化以及这些动态变化如何影响随后的信号传导的理解是我们了解淋巴细胞激活过程的过程的关键部分。