Genetic regulatory mechanisms: studies on genes responsive to ethanol

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The long-term goal of this research is to uncover and understand mechanisms underlying regulation of eukaryotic genes using mouse as the model and train graduates in the field of genetics. The genes for this research have been identified by mouse expression arrays using brain RNA from two strains; C57BL/6J and DBA/2J. The results have established that the strains differ for ~2% of the genes. Besides the strain specific (SS) differences we have identified genes that are ethanol responsive (ER) and strain specific ethanol responsive (SSER). This variation is critical in adaptation including sensitivity to external challenges and allowed us to propose a genomics approach to link this variation to sensitivities and behaviours (Singh et al 2007).This proposal deals with two questions;