Low Coordinate Main Group Chemistry: Discovery and Innovation

低配位主族化学：发现与创新

• 批准号: 37397-2012
• 负责人: Baines, Kim
• 金额: $ 5.1万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521472
• 关键词: Low; Coordinate; Main; Group; Chemistry

Beginning with the synthesis of stable, unsaturated derivatives of the heavier group 13 to 15 elements in the late 1970s to early 1980s, an impressive number of compounds once thought to be "non-existent" have now been synthesized, a true testament to the determination and skill of the global main group synthetic chemistry community. The driving force behind this area of research was often the innate curiosity of academic chemists who were inspired by the challenging syntheses and who desired to understand the bonding in these important, fundamental species. Furthermore, such molecules were, most often, the best and only starting materials for the construction of novel molecular targets. The recent discoveries of a stable distannyne (triply bonded tin derivative) which undergoes a reversible addition reaction (a key step in catalytic transformations), of stable silyl cations which are vital players in the catalytic degradation of environmental pollutants such as organofluorides and polyethers and of germanium cations which are envisioned as unique catalysts for the asymmetric synthesis of advanced pharmaceutical intermediates have dramatically shifted the perception of the value of this area of chemistry. Unsaturated main group compounds now offer an unexplored avenue of inquiry in the global search for innovative solutions for the major challenges facing today's world. The future for these compounds has never been brighter. Over the next granting period, we will explore the synthesis and the mechanistic chemistry of unsaturated main group compounds with the goal of providing to the scientific community a detailed understanding of the reactivity of these compounds, something that is critically needed if the potential of this class of molecules is to be realized.

从1970年代末到1980年代初合成13至15重族元素的稳定不饱和衍生物开始，现在已经合成了大量曾经被认为是“不存在”的化合物，这是全球主族合成化学界决心和技能的真实证明。这一研究领域背后的驱动力往往是学术化学家天生的好奇心，他们受到具有挑战性的合成的启发，并希望了解这些重要的基本物种中的键合。此外，这些分子通常是构建新型分子靶点的最佳和唯一起始材料。最近发现的一种稳定的distannyne（三键合的锡衍生物），其经历可逆加成反应（催化转化的关键步骤），稳定的甲硅烷基阳离子（其在催化降解环境污染物如有机氟化物和聚醚中是重要的参与者）和锗阳离子（其被设想为用于高级药物中间体的不对称合成的独特催化剂）的存在已经显著地改变了对这一化学领域价值的认知。不饱和主族化合物现在提供了一个未开发的调查途径，在全球范围内寻找创新的解决方案，为当今世界面临的主要挑战。这些化合物的未来从未如此光明。在下一个授予期间，我们将探索不饱和主族化合物的合成和机械化学，目的是为科学界提供对这些化合物反应性的详细了解，如果要实现这类分子的潜力，这是非常需要的。