Applications and methods of NMR in the study of biological materials

核磁共振在生物材料研究中的应用和方法

• 批准号: 227456-2009
• 负责人: Michal, Carl
• 金额: $ 1.75万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=523986
• 关键词: Applications; methods; NMR; study; biological

The proposed research program has a number of facets centered on the study of biological materials using solid-state nuclear magnetic resonance (NMR). Resilin is a rubber-like protein produced by insects. Our laboratory, in collaboration with others at UBC and in Australia are working on understanding the microscopic basis for its mechanical properties. Our Australian collaborators have produced a synthetic version of resilin on which we are performing NMR experiments that probe the molecular structure and dynamics. We plan to more thoroughly study both the synthetic protein as well as a naturally occurring resilin from dragonflies.

拟议的研究计划有许多方面集中在使用固态核磁共振（NMR）的生物材料的研究。Resilin是一种由昆虫产生的橡胶状蛋白质。 我们的实验室与UBC和澳大利亚的其他实验室合作，正在努力了解其机械性能的微观基础。 我们的澳大利亚合作者已经生产出了一种合成的节枝弹性蛋白，我们正在对其进行核磁共振实验，以探测分子结构和动力学。 我们计划更彻底地研究合成蛋白质以及蜻蜓中天然存在的弹性蛋白。