Modulation of membrane architecture and function by physiologically relevant and toxic ions

生理相关和有毒离子对膜结构和功能的调节

• 批准号: 261700-2012
• 负责人: Prenner, Elmar
• 金额: $ 1.82万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525339
• 关键词: Modulation; membrane; architecture; function; physiologically

Toxic metals are at the core of significant and growing concerns to the Natural Sciences and Engineering fields in Canada and beyond. Indeed, ion mixtures of toxic metals disrupt physiology via mechanisms that remain poorly understood. In accord with my long term research interest in the structure and function of biomembranes, this proposal addresses the impact of ions and toxic metals on membranes. The impact of essential ions Na+, K+ and Ca++ is compared with the common pollutants Cd++ and Hg++. Ion combinations are important since the human body is exposed to a mix of pollutants which may increase their effects. These ions differ in their toxicity as Cd++ was reported as a problem for wildlife whereas Hg++ is more a concern for domestic animals. Ion-membrane interactions are studied in four areas:

有毒金属是加拿大及其他地区自然科学和工程领域日益关注的重要问题。事实上，有毒金属的离子混合物通过仍然知之甚少的机制破坏生理。根据我对生物膜的结构和功能的长期研究兴趣，本提案涉及离子和有毒金属对膜的影响。比较了必需离子Na+、K+和Ca++与常见污染物Cd++和Hg++的影响。离子组合很重要，因为人体暴露在污染物的混合物中，这可能会增加它们的影响。这些离子的毒性各不相同，因为据报道，Cd++对野生动物有危害，而Hg++对家畜更有危害。离子-膜相互作用研究在四个方面：