Molecular basis of protein-ligand interactions.

蛋白质-配体相互作用的分子基础。

• 批准号: 262073-2010
• 负责人: Bisaillon, Martin
• 金额: $ 2.91万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525484
• 关键词: Molecular; basis; protein; ligand; interactions.

The long-term objective of this research program is to understand the fundamental molecular mechanisms that dictate the interactions between enzymes and their ligands. More specifically, our goal is to understand the biological functions of proteins in terms of their molecular interactions with specific ligands. We take a multidisciplinary approach with particular emphasis on biophysical approaches to decipher the kinetic pathways, structural modifications, and thermodynamics involved in various aspects of gene expression. We are focusing on distinct proteins from West Nile virus (WNV) involved in the expression of the viral genome as powerful models to understand the molecular determinants involved in their interactions with specific ligands. In the current research program, we are focusing on two different proteins from WNV and use them as powerful models to understand how proteins interact with ligands.

该研究计划的长期目标是了解决定酶及其配体之间相互作用的基本分子机制。更具体地说，我们的目标是了解蛋白质与特定配体分子相互作用的生物学功能。我们采取多学科的方法，特别强调生物物理方法来破译基因表达的各个方面所涉及的动力学途径，结构修饰和热力学。我们专注于不同的蛋白质从西尼罗河病毒（WNV）参与病毒基因组的表达作为强大的模型，以了解参与其与特定配体的相互作用的分子决定因素。在目前的研究计划中，我们专注于来自WNV的两种不同蛋白质，并将它们作为强大的模型来了解蛋白质如何与配体相互作用。