Molecular basis of protein-ligand interactions.

蛋白质-配体相互作用的分子基础。

• 批准号: RGPIN-2015-05057
• 负责人: Bisaillon, Martin
• 金额: $ 2.19万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590193
• 关键词: Molecular; basis; protein; ligand; interactions.

The long-term objective of this research program is to understand the molecular mechanisms that dictate the interactions between proteins and their ligands. We are especially interested in proteins that interact with RNA, metal ions, and/or other proteins because there are still important gaps in our understanding of how proteins recognize these ligands. Viral proteins are especially well suited for these studies because a single protein frequently harbors many different enzymatic activities and can therefore interact with various ligands. In the current research program, we are focusing on two different proteins (NS4B and NS5A) from the Hepatitis C virus (HCV) and use them as powerful models to understand how proteins interact with ligands.

该研究计划的长期目标是了解决定蛋白质及其配体之间相互作用的分子机制。我们对与RNA、金属离子和/或其他蛋白质相互作用的蛋白质特别感兴趣，因为我们对蛋白质如何识别这些配体的理解仍然存在重要差距。病毒蛋白特别适合于这些研究，因为单个蛋白质通常具有许多不同的酶活性，因此可以与各种配体相互作用。在目前的研究计划中，我们专注于丙型肝炎病毒（HCV）的两种不同蛋白质（NS 4 B和NS 5A），并将它们作为强大的模型来了解蛋白质如何与配体相互作用。